Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50177321
Substrate
n/a
Meas. Tech.
ChEMBL_331857 (CHEMBL865873)
IC50
7550±n/a nM
Citation
 Cho, SYBaek, JYHan, SSKang, SKHa, JDAhn, JHLee, JDKim, KRCheon, HGRhee, SDYang, SDYon, GHPak, CSChoi, JK PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives. Bioorg Med Chem Lett 16:499-502 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50177321
Synonyms:
2-(4-(7-(3-(trifluoromethyl)benzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acid | CHEMBL202573
Type:
Small organic molecule
Emp. Form.:
C23H14F3NO5
Mol. Mass.:
441.3562
SMILES:
OC(=O)COc1ccc(cc1)-c1nocc2c(ccc12)C(=O)c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: