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Target
Tyrosine-protein phosphatase YopH
Ligand
BDBM50177317
Substrate
n/a
Meas. Tech.
ChEMBL_331859 (CHEMBL865877)
IC50
5710±n/a nM
Citation
 Cho, SY; Baek, JY; Han, SS; Kang, SK; Ha, JD; Ahn, JH; Lee, JD; Kim, KR; Cheon, HG; Rhee, SD; Yang, SD; Yon, GH; Pak, CS; Choi, JK PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives. Bioorg Med Chem Lett 16:499-502 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase YopH
Synonyms:
YOPH_YEREN | yop51 | yopH
Type:
PROTEIN
Mol. Mass.:
50951.99
Organism:
Yersinia enterocolitica
Description:
ChEMBL_965525
Residue:
468
Sequence:
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
  
Inhibitor
Name:
BDBM50177317
Synonyms:
2-(4-(7-(4-methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acid | CHEMBL201662
Type:
Small organic molecule
Emp. Form.:
C23H17NO6
Mol. Mass.:
403.3842
SMILES:
COc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Structure:
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