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Target
Cathepsin K
Ligand
BDBM50177499
Substrate
n/a
Meas. Tech.
ChEMBL_334148 (CHEMBL868299)
IC50
470±n/a nM
Citation
 Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 16:978-83 (2006) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50177499
Synonyms:
CHEMBL204907 | ethyl 3-({N'-[(1E,2S)-2-{[(tert-butoxy)carbonyl]amino}hexylidene]hydrazinecarbonyl}amino)propanoate
Type:
Small organic molecule
Emp. Form.:
C17H32N4O5
Mol. Mass.:
372.4598
SMILES:
CCCC[C@H](NC(=O)OC(C)(C)C)C=NNC(=O)NCCC(=O)OCC |w:14.14|
Structure:
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