Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50148292
Substrate
n/a
Meas. Tech.
ChEMBL_334151 (CHEMBL868302)
IC50
2000±n/a nM
Citation
Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 16:978-83 (2006) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM50148292
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid 1-benzyl-cyclopentyl ester | (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate | 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE | CHEMBL117658
Type:
Small organic molecule
Emp. Form.:
C19H27NO3
Mol. Mass.:
317.4226
SMILES:
CCCC[C@H](NC(=O)OC1(Cc2ccccc2)CCCC1)C=O