Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50177501
Substrate
n/a
Meas. Tech.
ChEMBL_334151 (CHEMBL868302)
IC50
12±n/a nM
Citation
Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 16:978-83 (2006) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM50177501
Synonyms:
CHEMBL203663 | {(S)-1-[(morpholine-4-carbonyl)-hydrazonomethyl]-pentyl}-carbamic acid (R)-1-benzyl-2-methyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C23H36N4O4
Mol. Mass.:
432.5563
SMILES:
CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=NNC(=O)N1CCOCC1 |w:21.22|