Target
Histamine H3 receptor
Ligand
BDBM50177525
Substrate
n/a
Meas. Tech.
ChEMBL_334179 (CHEMBL866473)
Ki
315±n/a nM
Citation
 Berlin, MTing, PCVaccaro, WDAslanian, RMcCormick, KDLee, JFAlbanese, MMMutahi, MWPiwinski, JJShih, NYDuguma, LSolomon, DMZhou, WSher, RFavreau, LBryant, MKorfmacher, WANardo, CWest, REAnthes, JCWilliams, SMWu, RLSusan She, HRivelli, MACorboz, MRHey, JA Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:989-94 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50177525
Synonyms:
1-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-one | CHEMBL203912
Type:
Small organic molecule
Emp. Form.:
C24H34N4O2
Mol. Mass.:
410.5524
SMILES:
O=C(CCOc1ccc(CN2CCCCC2)cc1)N1CCC(Cc2cnc[nH]2)CC1
Structure:
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