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Target
Dynamin-1
Ligand
BDBM5162
Substrate
n/a
Meas. Tech.
ChEMBL_326472 (CHEMBL864467)
IC50
>100000±n/a nM
Citation
 Hill, T; Odell, LR; Edwards, JK; Graham, ME; McGeachie, AB; Rusak, J; Quan, A; Abagyan, R; Scott, JL; Robinson, PJ; McCluskey, A Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins. J Med Chem 48:7781-8 (2005) [PubMed]  Article 
Target
Name:
Dynamin-1
Synonyms:
DNM | DNM1 | DYN1_HUMAN | Dynamin-1
Type:
PROTEIN
Mol. Mass.:
97411.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458576
Residue:
864
Sequence:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL
  
Inhibitor
Name:
BDBM5162
Synonyms:
(2E)-2-({4-[(2E)-2-cyano-2-[(3,4-dihydroxyphenyl)methylidene]acetyl]piperazin-1-yl}carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile | CHEMBL358494 | Dimeric Tyrphostin 15
Type:
Small organic molecule
Emp. Form.:
C24H20N4O6
Mol. Mass.:
460.4388
SMILES:
Oc1ccc(\C=C(/C#N)C(=O)N2CCN(CC2)C(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O
Structure:
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