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Target
Excitatory amino acid transporter 2
Ligand
BDBM50031704
Substrate
n/a
Meas. Tech.
ChEMBL_326369 (CHEMBL859748)
Ki
13000±n/a nM
Citation
 Alaux, S; Kusk, M; Sagot, E; Bolte, J; Jensen, AA; Bräuner-Osborne, H; Gefflaut, T; Bunch, L Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. J Med Chem 48:7980-92 (2005) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 2
Synonyms:
EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62103.57
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT2 0 0::P43004
Residue:
574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
  
Inhibitor
Name:
BDBM50031704
Synonyms:
(2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-amino-4-methylpentanedioic acid | (2S,4R)-4-methylglutamic acid | 2-Amino-4-methyl-pentanedioic acid | CHEMBL288166
Type:
Small organic molecule
Emp. Form.:
C6H11NO4
Mol. Mass.:
161.1558
SMILES:
C[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Structure:
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