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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50179609
Substrate
n/a
Meas. Tech.
ChEMBL_336082 (CHEMBL865933)
IC50
200±n/a nM
Citation
 Sakya, SM; Cheng, H; Lundy Demello, KM; Shavnya, A; Minich, ML; Rast, B; Dutra, J; Li, C; Rafka, RJ; Koss, DA; Li, J; Jaynes, BH; Ziegler, CB; Mann, DW; Petras, CF; Seibel, SB; Silvia, AM; George, DM; Hickman, A; Haven, ML; Lynch, MP 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. Bioorg Med Chem Lett 16:1202-6 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Type:
PROTEIN
Mol. Mass.:
69314.28
Organism:
Canis familiaris
Description:
ChEMBL_327426
Residue:
603
Sequence:
MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVLTARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLLGRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHYGIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPSTEL
  
Inhibitor
Name:
BDBM50179609
Synonyms:
1-(5-(methylsulfonyl)pyridin-2-yl)-5-(phenylthio)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile | CHEMBL381158
Type:
Small organic molecule
Emp. Form.:
C17H11F3N4O2S2
Mol. Mass.:
424.42
SMILES:
CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1Sc1ccccc1)C(F)(F)F
Structure:
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