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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM20164
Substrate
n/a
Meas. Tech.
ChEMBL_340909 (CHEMBL860635)
EC50
500±n/a nM
Citation
 Li, L; Liu, J; Zhu, L; Cutler, S; Hasegawa, H; Shan, B; Medina, JC Discovery and optimization of a novel series of liver X receptor-alpha agonists. Bioorg Med Chem Lett 16:1638-42 (2006) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM20164
Synonyms:
(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-4-[(2S)-3,3-dimethyloxiran-2-yl]butan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol | 24(S),25-epoxycholesterol | CHEMBL434302 | Epoxycholesterol
Type:
Steroid
Emp. Form.:
C27H44O2
Mol. Mass.:
400.6371
SMILES:
[H][C@@]1(CC[C@@H](C)[C@@]2([H])CC[C@@]3([H])[C@]4([H])CC=C5C[C@@]([H])(O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)OC1(C)C |r,t:15|
Structure:
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