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Target
Phospholipase B
Ligand
BDBM50180985
Substrate
n/a
Meas. Tech.
ChEMBL_330127 (CHEMBL858987)
IC50
7500±n/a nM
Citation
 Ng, CK; Obando, D; Widmer, F; Wright, LC; Sorrell, TC; Jolliffe, KA Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts. J Med Chem 49:811-6 (2006) [PubMed]  Article 
Target
Name:
Phospholipase B
Synonyms:
PLB | PLB1 | PLB1_CRYNB
Type:
PROTEIN
Mol. Mass.:
68557.23
Organism:
Cryptococcus neoformans
Description:
ChEMBL_330127
Residue:
637
Sequence:
MSIITTAFALSLLATTAFAVPPETPRIELQAERGLGDQSYAPWQVDCPSNVTWIRNATTGLGTGERAYIEAREKLVQPAIEQMMAARGLETPPRTPVIGVALAGGGYRAMLTGLGGIMGMMNESTEASQSETGGWLDGVSYWSGLSGGSWATGSFMSNGGQLPTTLLENLWNIDSNLVFPDDGKLSFYTNLYTETNAKSDLGFPVQITDIWGLAIGSHVLPEPYQLSNTPNLTFSSLPSVVAALGNASLPMPIIVAADRKRREAGELVIAENATVWEFTPYEFGSWAFGSQYKSPGAFTPIEYLGTSVDDGSPNGTCWKGFDQLSFVMGTSATLFNGAFLELNGTDSGLLTNLITAFLADLGEDQADISRIPNSFSNYNSGENPIYNLTYITLVDAGETNQNIPLEPLLVPTRDVDAIVAFDSSYDSDYIWPNGTALRTTYERAKILAEHENTRVLMPEVPSMNGFVNGGYNSRPTFFGCNDTTTPVIIYIPSYPWSFAANTSTYQLSYENNEANEMLLNGMRSLTLNHSVPTWPTCFACALTDRSFMYTSENRSTTCQECFDTWCWAGDDNTTEPANYEPVINSVPPWLIANNLSIGMADAPGSNESTAGTASSGAAKMGVGMGMVALTAGLGLML
  
Inhibitor
Name:
BDBM50180985
Synonyms:
1,12-Bis(trihexyl ammonium)dodecane dichloride | CHEMBL199345
Type:
Small organic molecule
Emp. Form.:
C48H102N2
Mol. Mass.:
707.3358
SMILES:
CCCCCC[N+](CCCCCC)(CCCCCC)CCCCCCCCCCCC[N+](CCCCCC)(CCCCCC)CCCCCC
Structure:
Search PDB for entries with ligand similarity: