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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50181273
Substrate
n/a
Meas. Tech.
ChEMBL_345140 (CHEMBL869624)
IC50
>3200±n/a nM
Citation
 Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett 16:1799-802 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_RAT | Prostanoid EP2 receptor | Ptger2
Type:
PROTEIN
Mol. Mass.:
39786.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1501400
Residue:
357
Sequence:
MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
  
Inhibitor
Name:
BDBM50181273
Synonyms:
7-[(S)-2-((R)-4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | CHEMBL208399
Type:
Small organic molecule
Emp. Form.:
C27H35NO4
Mol. Mass.:
437.5711
SMILES:
O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)-c1ccccc1
Structure:
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