Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50181294
Substrate
n/a
Meas. Tech.
ChEMBL_345140 (CHEMBL869624)
IC50
125±n/a nM
Citation
Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett 16:1799-802 (2006) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_RAT | Prostanoid EP2 receptor | Ptger2
Type:
PROTEIN
Mol. Mass.:
39786.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1501400
Residue:
357
Sequence:
MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
Inhibitor
Name:
BDBM50181294
Synonyms:
5-{3-[(S)-2-(4-biphenyl-2-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid | CHEMBL379785
Type:
Small organic molecule
Emp. Form.:
C28H31NO4S
Mol. Mass.:
477.615
SMILES:
OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccccc1-c1ccccc1