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Target
HLA class II histocompatibility antigen gamma chain
Ligand
BDBM50182114
Substrate
n/a
Meas. Tech.
ChEMBL_347360 (CHEMBL865649)
IC50
2600±n/a nM
Citation
 Grice, CA; Tays, K; Khatuya, H; Gustin, DJ; Butler, CR; Wei, J; Sehon, CA; Sun, S; Gu, Y; Jiang, W; Thurmond, RL; Karlsson, L; Edwards, JP The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors. Bioorg Med Chem Lett 16:2209-12 (2006) [PubMed]  Article 
Target
Name:
HLA class II histocompatibility antigen gamma chain
Synonyms:
CD74 | DHLAG | HG2A_HUMAN | HLA-DR antigens-associated invariant chain
Type:
PROTEIN
Mol. Mass.:
33525.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_347360
Residue:
296
Sequence:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
  
Inhibitor
Name:
BDBM50182114
Synonyms:
4-(1-(3-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL380541
Type:
Small organic molecule
Emp. Form.:
C29H33BrClN5O4S
Mol. Mass.:
663.025
SMILES:
CS(=O)(=O)N1CCc2c(C1)c(nn2CCCN1CCC(CC1)N1C(=O)COc2ccc(Cl)cc12)-c1ccc(Br)cc1
Structure:
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