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Target
cGMP-dependent protein kinase
Ligand
BDBM50182359
Substrate
n/a
Meas. Tech.
ChEMBL_349021 (CHEMBL865064)
IC50
0.081±n/a nM
Citation
 Biftu, T; Feng, D; Fisher, M; Liang, GB; Qian, X; Scribner, A; Dennis, R; Lee, S; Liberator, PA; Brown, C; Gurnett, A; Leavitt, PS; Thompson, D; Mathew, J; Misura, A; Samaras, S; Tamas, T; Sina, JF; McNulty, KA; McKnight, CG; Schmatz, DM; Wyvratt, M Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents. Bioorg Med Chem Lett 16:2479-83 (2006) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
112911.27
Organism:
Eimeria tenella
Description:
ChEMBL_469577
Residue:
1003
Sequence:
MGACSSKAQHQTRDPEPREQQAAQEQKSTGPSGAPNDAPAPAEAERKMSGSSATAPKGEMPTASTGTPEQQQQQQQQQQQQQEQQQHPEHQQSEKQQQHGEEQQQERKPSQQQQNEEAAAPHKHGGERKVQKAIKQQEDTQAEDARLLGHLEKREKTPSDLSLIRDSLSTNLVCSSLNDAEVEALANAVEFFTFKKGDVVTKQGESGSYFFIVHSGEFEVIVNDKVVNKILTGQAFGEISLIHNSARTATIKTLSEDAALWGVQRQVFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVQSFQPGQAIVKEGEKGDVLYILKSGKALVSIKNKEVRVLQRGEYFGERALLYDEPRSATITAEEPTVCVSIGRDLLDRVLGNLQHVLFRNIMLEALQQSKVFASFPTEQLSRLIGSVVVKDYPENYIILDRENRTRASASALFSAQGVRFFFVLEGEVSVFAYKDKSSSSSSSSSSSSSSSSAEGEMELHLIDTLKRGQAFGDEYVLSPNKPFAHCVKSNGPTKLALLTASALTATLGGQDIDETLDYNNKLAITKKMYIFRYLSEQQTQTLIKAFKTVRYTQGESIIREGEIGSRFFIIKLGEVVILKGEKRVRTLGRHDYFGERALLHDERRSATVAANSPEVDLWVVDKDVFLQIVKGPMLTHLEERIRMQDTKVEFKDLNVVRVVGRGTFGTVKLVQHIPTQMRYALKCVSRKSVVALNQQDHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILAGKLIFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFSDFDWDRLAGRDLSPPLLPKGEIYAEDAEEGGLDIEEDEGIELEDEYEWDKDF
  
Inhibitor
Name:
BDBM50182359
Synonyms:
CHEMBL379059 | N-benzyl-4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
Type:
Small organic molecule
Emp. Form.:
C27H25FN6
Mol. Mass.:
452.526
SMILES:
CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: