Reaction Details
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Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50182630
Substrate
n/a
Meas. Tech.
ChEMBL_334895 (CHEMBL861270)
EC50
2500±n/a nM
Citation
Harvey, AJ; Baell, JB; Toovey, N; Homerick, D; Wulff, H A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. J Med Chem 49:1433-41 (2006) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
KCNA3_MOUSE | Kcna3 | MK3 | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
58553.58
Organism:
Mus musculus
Description:
ChEMBL_1513943
Residue:
528
Sequence:
MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
Inhibitor
Name:
BDBM50182630
Synonyms:
1-(4-(benzyloxy)-6-hydroxy-7-methoxybenzofuran-5-yl)ethanone | CHEMBL203798
Type:
Small organic molecule
Emp. Form.:
C18H16O5
Mol. Mass.:
312.3166
SMILES:
COc1c(O)c(C(C)=O)c(OCc2ccccc2)c2ccoc12
Structure:
