Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50127708
Substrate
n/a
Meas. Tech.
ChEMBL_351034 (CHEMBL866259)
IC50
20900±n/a nM
Citation
 Beevers, REBuckley, GMDavies, NFraser, JLGalvin, FCHannah, DRHaughan, AFJenkins, KMack, SRPitt, WRRatcliffe, AJRichard, MDSabin, VSharpe, AWilliams, SC Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett 16:2535-8 (2006) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50127708
Synonyms:
(1H)-indole-3-carbonitrile | 1H-Indole-3-carbonitrile | CHEMBL46724
Type:
Small organic molecule
Emp. Form.:
C9H6N2
Mol. Mass.:
142.1573
SMILES:
N#Cc1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: