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Target
Mu-type opioid receptor
Ligand
BDBM50182945
Substrate
n/a
Meas. Tech.
ChEMBL_349386 (CHEMBL863863)
Ki
18±n/a nM
Citation
 Breslin, HJ; Cai, C; Miskowski, TA; Coutinho, SV; Zhang, SP; Hornby, P; He, W Identification of potent phenyl imidazoles as opioid receptor agonists. Bioorg Med Chem Lett 16:2505-8 (2006) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50182945
Synonyms:
(S)-2-amino-3-phenyl-1-((S)-2-(4-phenyl-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one | CHEMBL208164
Type:
Small organic molecule
Emp. Form.:
C23H26N4O
Mol. Mass.:
374.4787
SMILES:
N[C@@H](Cc1ccccc1)C(=O)N1CCCC[C@H]1c1nc(c[nH]1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: