Reaction Details Report a problem with these data
Target
Sodium-dependent serotonin transporter
Ligand
BDBM50183170
Substrate
n/a
Meas. Tech.
ChEMBL_355134 (CHEMBL853187)
Ki
2.5±n/a nM
Citation
 Boot, JR; Boulet, SL; Clark, BP; Cases-Thomas, MJ; Delhaye, L; Diker, K; Fairhurst, J; Findlay, J; Gallagher, PT; Gilmore, J; Harris, JR; Masters, JJ; Mitchell, SN; Naik, M; Simmonds, RG; Smith, SM; Richards, SJ; Timms, GH; Whatton, MA; Wolfe, CN; Wood, VA N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 16:2714-8 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50183170
Synonyms:
CHEMBL207480 | N-(4-fluoro-2-(trifluoromethyl)benzyl)-N-(cyclobutylmethyl)piperidin-4-amine tartaric acid salt
Type:
Small organic molecule
Emp. Form.:
C18H24F4N2
Mol. Mass.:
344.3902
SMILES:
Fc1ccc(CN(CC2CCC2)C2CCNCC2)c(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: