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Target
Alpha-1D adrenergic receptor
Ligand
BDBM50131403
Substrate
n/a
Meas. Tech.
ChEMBL_350832 (CHEMBL869686)
EC50
>10000±n/a nM
Citation
 del Olmo, E; Barboza, B; Ybarra, MI; López-Pérez, JL; Carrón, R; Sevilla, MA; Boselli, C; San Feliciano, A Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett 16:2786-90 (2006) [PubMed]  Article 
Target
Name:
Alpha-1D adrenergic receptor
Synonyms:
ADA1D_RAT | Adra1a | Adra1d | Alpha adrenergic receptor 1A and 1D | Alpha-1D adrenergic receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1
Type:
Protein
Mol. Mass.:
59375.97
Organism:
Rattus norvegicus (Rat)
Description:
P23944
Residue:
561
Sequence:
MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
  
Inhibitor
Name:
BDBM50131403
Synonyms:
2-Methyl-4-(3,4,5-trimethoxy-benzyl)-2H-phthalazin-1-one | 4-(3,4,5-trimethoxybenzyl)-2-methylphthalazin-1(2H)-one | 4-Benzo[1,3]dioxol-5-ylmethyl-2-methyl-2H-phthalazin-1-one | CHEMBL308666
Type:
Small organic molecule
Emp. Form.:
C19H20N2O4
Mol. Mass.:
340.3731
SMILES:
COc1cc(Cc2nn(C)c(=O)c3ccccc23)cc(OC)c1OC
Structure:
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