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Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50184153
Substrate
n/a
Meas. Tech.
ChEMBL_364710 (CHEMBL866306)
IC50
1.68±n/a nM
Citation
 Li, J; Bertinato, P; Cheng, H; Cole, BM; Bronk, BS; Jaynes, BH; Hickman, A; Haven, ML; Kolosko, NL; Barry, CJ; Manion, TB Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorg Med Chem Lett 16:3039-42 (2006) [PubMed]  Article 
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:
PROTEIN
Mol. Mass.:
99365.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_971724
Residue:
894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
  
Inhibitor
Name:
BDBM50184153
Synonyms:
4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{[(S)-(cyclopropylmethyl-carbamoyl)-phenyl-methyl]-carbamoyl}-2-methoxy-phenyl)-amide | CHEMBL207354
Type:
Small organic molecule
Emp. Form.:
C34H30F3N3O4
Mol. Mass.:
601.6149
SMILES:
COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: