Target
B1 bradykinin receptor
Ligand
BDBM50184188
Substrate
n/a
Meas. Tech.
ChEMBL_350972 (CHEMBL858907)
Ki
2.2±n/a nM
Citation
 Kuduk, SDDi Marco, CNChang, RKWood, MRKim, JJSchirripa, KMMurphy, KLRansom, RWTang, CTorrent, MHa, SPrueksaritanont, TPettibone, DJBock, MG 5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists. Bioorg Med Chem Lett 16:2791-5 (2006) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50184188
Synonyms:
3,3'-difluoro-4'-{[5-(4-isopropyl-piperazine-1-carbonyl)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester | CHEMBL437704
Type:
Small organic molecule
Emp. Form.:
C28H30F2N4O3
Mol. Mass.:
508.5596
SMILES:
COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(cn2)C(=O)N2CCN(CC2)C(C)C)c(F)c1
Structure:
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