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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50184251
Substrate
n/a
Meas. Tech.
ChEMBL_364825 (CHEMBL870172)
EC50
5100±n/a nM
Citation
 Szewczyk, JW; Huang, S; Chin, J; Tian, J; Mitnaul, L; Rosa, RL; Peterson, L; Sparrow, CP; Adams, AD SAR studies: designing potent and selective LXR agonists. Bioorg Med Chem Lett 16:3055-60 (2006) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50184251
Synonyms:
4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)benzoic acid | CHEMBL207142
Type:
Small organic molecule
Emp. Form.:
C22H23F3N2O4
Mol. Mass.:
436.4242
SMILES:
CCCc1c(OCCCN(C)c2ccc(cc2)C(O)=O)ccc2c(noc12)C(F)(F)F
Structure:
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