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Target
C-C chemokine receptor type 7
Ligand
BDBM50422828
Substrate
n/a
Meas. Tech.
ChEMBL_338819 (CHEMBL860704)
IC50
>10000±n/a nM
Citation
 Seto, M; Aikawa, K; Miyamoto, N; Aramaki, Y; Kanzaki, N; Takashima, K; Kuze, Y; Iizawa, Y; Baba, M; Shiraishi, M Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety. J Med Chem 49:2037-48 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 7
Synonyms:
CCR7 | CCR7_HUMAN | CMKBR7 | EBI1 | EVI1
Type:
PROTEIN
Mol. Mass.:
42885.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_338819
Residue:
378
Sequence:
MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
  
Inhibitor
Name:
BDBM50422828
Synonyms:
CENICRIVIROC | CENICRIVIROC MESYLATE | TAK-652 | TBR-652
Type:
Small organic molecule
Emp. Form.:
C41H52N4O4S
Mol. Mass.:
696.941
SMILES:
CCCCOCCOc1ccc(cc1)-c1ccc2N(CC(C)C)CCCC(=Cc2c1)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC |r,w:27.28|
Structure:
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