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Target
Mitogen-activated protein kinase kinase kinase 20
Ligand
BDBM50184491
Substrate
n/a
Meas. Tech.
ChEMBL_337604 (CHEMBL861565)
IC50
4880±n/a nM
Citation
 Li, HY; Wang, Y; Heap, CR; King, CH; Mundla, SR; Voss, M; Clawson, DK; Yan, L; Campbell, RM; Anderson, BD; Wagner, JR; Britt, K; Lu, KX; McMillen, WT; Yingling, JM Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem 49:2138-42 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase kinase kinase 20
Synonyms:
M3K20_HUMAN | MAP3K20 | MLK7 | MLTK | Mixed lineage kinase 7 | ZAK
Type:
PROTEIN
Mol. Mass.:
91168.58
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1495629
Residue:
800
Sequence:
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
  
Inhibitor
Name:
BDBM50184491
Synonyms:
6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(3-(pyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole | 6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(3-pyrrolidin-1-ylpropyl)-1H-benzoimidazole | CHEMBL378167
Type:
Small organic molecule
Emp. Form.:
C25H28N6
Mol. Mass.:
412.53
SMILES:
C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: