Reaction Details Report a problem with these data
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50153713
Substrate
n/a
Meas. Tech.
ChEMBL_344886 (CHEMBL870710)
IC50
48±n/a nM
Citation
 Devreux, V; Wiesner, J; Goeman, JL; Van der Eycken, J; Jomaa, H; Van Calenbergh, S Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. J Med Chem 49:2656-60 (2006) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM
Type:
Protein
Mol. Mass.:
43384.52
Organism:
Escherichia coli
Description:
P45568
Residue:
398
Sequence:
MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
  
Inhibitor
Name:
BDBM50153713
Synonyms:
3-(N-hydroxyformamido)propylphosphonic acid | 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID | CHEMBL203125 | [3-(Formyl-hydroxy-amino)-propyl]-phosphonic acid | fosmidomycin
Type:
Small organic molecule
Emp. Form.:
C4H10NO5P
Mol. Mass.:
183.0997
SMILES:
ON(CCCP(O)(O)=O)C=O
Structure:
Search PDB for entries with ligand similarity: