Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50186127
Substrate
n/a
Meas. Tech.
ChEMBL_371315 (CHEMBL865536)
Ki
3.00±n/a nM
Citation
 Briner, K; Collado, I; Fisher, MJ; García-Paredes, C; Husain, S; Kuklish, SL; Mateo, AI; O'Brien, TP; Ornstein, PL; Zgombick, J; de Frutos, O Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives. Bioorg Med Chem Lett 16:3449-53 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50186127
Synonyms:
CHEMBL378408 | N-[(R)-2-{4-[2-(acetyl-ethyl-amino)-1-cyclohexyl-ethyl]-piperazin-1-yl}-1-(4-chloro-benzyl)-2-oxo-ethyl]-2-(2,3-dihydro-1H-indol-2-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C35H48ClN5O3
Mol. Mass.:
622.24
SMILES:
CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)C(C)=O
Structure:
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