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Target
Proteasome subunit beta type-1
Ligand
BDBM50185154
Substrate
n/a
Meas. Tech.
ChEMBL_353296 (CHEMBL861975)
IC50
2200±n/a nM
Citation
 Rydzewski, RM; Burrill, L; Mendonca, R; Palmer, JT; Rice, M; Tahilramani, R; Bass, KE; Leung, L; Gjerstad, E; Janc, JW; Pan, L Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J Med Chem 49:2953-68 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50185154
Synonyms:
(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic acid ((S)-1-{(R)-(R)-2-hydroxy-1-[(R)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propylcarbamoyl}-2-methyl-butyl)-amide | (2S,3S)-2-[(2S,3S)-2-(acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(2S,3R)-3-hydroxy-2-[3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylamino]-butyryl}-amide | (S)-2-[(R)-(S)-2-((R)-Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(R)-2-hydroxy-1-[(R)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide | CHEMBL207990 | Epoxomicin | epoxomycin
Type:
Small organic molecule
Emp. Form.:
C28H50N4O7
Mol. Mass.:
554.7192
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(C)=O)C(=O)NC(=O)[C@@H](NC(CC(C)C)C(=O)[C@@]1(C)CO1)[C@@H](C)O
Structure:
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