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Target20S proteasome chymotrypsin-like
LigandBDBM50069984
Substrate/Competitorn/a
Meas. Tech.ChEMBL_353294
Ki 2.3±n/a nM
Citation Rydzewski, RMBurrill, LMendonca, RPalmer, JTRice, MTahilramani, RBass, KELeung, LGjerstad, EJanc, JWPan, L Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J Med Chem49:2953-68 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
20S proteasome chymotrypsin-like
Name:20S proteasome chymotrypsin-like
Synonyms:26S proteosome | Proteasome Macropain subunit MB1
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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  Blast E-value cutoff:
BDBM50069984
NameBDBM50069984
Synonyms:(R)-1-((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutylboronic acid | CHEMBL114388 | Dipeptidyl boronic acid derivative
TypeSmall organic molecule
Emp. Form.C25H42BN3O6
Mol. Mass.491.428
SMILESCC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)B(O)O
Structure
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n/a