Target
Proteasome subunit beta type-2
Ligand
BDBM50410899
Substrate
n/a
Meas. Tech.
ChEMBL_353295 (CHEMBL861974)
Ki
>300000±n/a nM
Citation
 Rydzewski, RMBurrill, LMendonca, RPalmer, JTRice, MTahilramani, RBass, KELeung, LGjerstad, EJanc, JWPan, L Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J Med Chem 49:2953-68 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50410899
Synonyms:
CHEMBL383674
Type:
Small organic molecule
Emp. Form.:
C33H44N6O7S
Mol. Mass.:
668.803
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)c1nnc(o1)-c1ccccc1
Structure:
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