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Target
Thromboxane A2 receptor
Ligand
BDBM50188608
Substrate
n/a
Meas. Tech.
ChEMBL_364277 (CHEMBL863215)
IC50
0.56±n/a nM
Citation
 Hanson, J; Reynaud, D; Qiao, N; Devel, P; Moray, AL; Renard, JF; Kelley, LP; Winum, JY; Montero, JL; Kinsella, BT; Pirotte, B; Pace-Asciak, CR; Dogné, JM Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem 49:3701-9 (2006) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50188608
Synonyms:
CHEMBL209306 | N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nitrobenzenesulfonyl]urea
Type:
Small organic molecule
Emp. Form.:
C19H24N4O5S
Mol. Mass.:
420.483
SMILES:
Cc1cccc(C)c1Nc1ccc(cc1S(=O)(=O)NC(=O)NC(C)(C)C)[N+]([O-])=O
Structure:
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