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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50189647
Substrate
n/a
Meas. Tech.
ChEMBL_368413 (CHEMBL870503)
IC50
53±n/a nM
Citation
Combs, AP; Zhu, W; Crawley, ML; Glass, B; Polam, P; Sparks, RB; Modi, D; Takvorian, A; McLaughlin, E; Yue, EW; Wasserman, Z; Bower, M; Wei, M; Rupar, M; Ala, PJ; Reid, BM; Ellis, D; Gonneville, L; Emm, T; Taylor, N; Yeleswaram, S; Li, Y; Wynn, R; Burn, TC; Hollis, G; Liu, PC; Metcalf, B Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic. J Med Chem 49:3774-89 (2006) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
Inhibitor
Name:
BDBM50189647
Synonyms:
CHEMBL264833 | biphenyl-4-sulfonic acid {1-(5-cyano-1H-benzoimidazol-2-yl)-2-[4-(1,1,3-trioxo-1lambda*6*-isothiazolidin-5-yl)-phenyl]-ethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C31H25N5O5S2
Mol. Mass.:
611.691
SMILES:
O=C1CC(c2ccc(CC(NS(=O)(=O)c3ccc(cc3)-c3ccccc3)c3nc4ccc(cc4[nH]3)C#N)cc2)S(=O)(=O)N1