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Target
Calpain-2 catalytic subunit
Ligand
BDBM50189825
Substrate
n/a
Meas. Tech.
ChEMBL_367108 (CHEMBL863672)
IC50
120±n/a nM
Citation
 Shirasaki, Y; Nakamura, M; Yamaguchi, M; Miyashita, H; Sakai, O; Inoue, J Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives. J Med Chem 49:3926-32 (2006) [PubMed]  Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain
Type:
n/a
Mol. Mass.:
37789.71
Organism:
Sus scrofa
Description:
n/a
Residue:
324
Sequence:
YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRISKQLDSENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50189825
Synonyms:
(2S)-2-((((4-cyanophenyl)amino)thioxomethyl)amino)-4-methyl-N-((3S)-tetrahydro-2-hydroxy-3-furanyl)pentanamide | CHEMBL210347
Type:
Small organic molecule
Emp. Form.:
C18H24N4O3S
Mol. Mass.:
376.473
SMILES:
CC(C)C[C@H](NC(=S)Nc1ccc(cc1)C#N)C(=O)N[C@H]1CCOC1O
Structure:
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