Reaction Details Report a problem with these data
Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50177402
Substrate
n/a
Meas. Tech.
ChEMBL_391451 (CHEMBL870480)
IC50
150560±n/a nM
Citation
 Lota, RK; Dhanani, S; Owen, CP; Ahmed, S Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3). Bioorg Med Chem Lett 16:4519-22 (2006) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM50177402
Synonyms:
1-(4-hydroxy-phenyl)-propan-1-one | 1-(4-hydroxyphenyl)propan-1-one | 4'-Hydroxypropiophenone | CHEMBL312311 | Paroxypropione
Type:
Small organic molecule
Emp. Form.:
C9H10O2
Mol. Mass.:
150.1745
SMILES:
CCC(=O)c1ccc(O)cc1
Structure:
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