Reaction Details Report a problem with these data
Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50190416
Substrate
n/a
Meas. Tech.
ChEMBL_375433 (CHEMBL864146)
IC50
17±n/a nM
Citation
Cheng, JF; Huang, Y; Penuliar, R; Nishimoto, M; Liu, L; Arrhenius, T; Yang, G; O'leary, E; Barbosa, M; Barr, R; Dyck, JR; Lopaschuk, GD; Nadzan, AM Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem 49:4055-8 (2006) [PubMed] Article
More Info.:
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Inhibitor
Name:
BDBM50190416
Synonyms:
CHEMBL378896 | N-(3-(diisopropylamino)-3-oxopropyl)-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C16H23F6N3O4
Mol. Mass.:
435.3619
SMILES:
CC(C)N(C(C)C)C(=O)CCNC(=O)C1=NOC(C1)C(O)(C(F)(F)F)C(F)(F)F |t:14|