Target
Amiloride-sensitive sodium channel subunit alpha
Ligand
BDBM50190483
Substrate
n/a
Meas. Tech.
ChEMBL_375179 (CHEMBL868533)
IC50
48±n/a nM
Citation
 Hirsh, AJMolino, BFZhang, JAstakhova, NGeiss, WBSargent, BJSwenson, BDUsyatinsky, AWyle, MJBoucher, RCSmith, RTZamurs, AJohnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem 49:4098-115 (2006) [PubMed]  Article 
Target
Name:
Amiloride-sensitive sodium channel subunit alpha
Synonyms:
Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN
Type:
PROTEIN
Mol. Mass.:
75711.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_375179
Residue:
669
Sequence:
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
  
Inhibitor
Name:
BDBM50190483
Synonyms:
(4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino]-butyl}phenoxy)acetic acid | CHEMBL209017
Type:
Small organic molecule
Emp. Form.:
C18H22ClN7O4
Mol. Mass.:
435.865
SMILES:
NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)=O)cc1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: