Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM50192212
Substrate
n/a
Meas. Tech.
ChEMBL_401901 (CHEMBL906904)
EC50
17000±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Kapitskaya, M; Webber, AL; Petrukhin, K; Tang, YS; Dean, DC; Hartman, GD; Lindsley, CW Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand. Bioorg Med Chem Lett 16:5001-4 (2006) [PubMed]  Article 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM50192212
Synonyms:
2-chloro-N-(4-(5-(1-cyanocyclopropanecarboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)benzamide | CHEMBL215498
Type:
Small organic molecule
Emp. Form.:
C25H18ClN5O2
Mol. Mass.:
455.896
SMILES:
Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nc2ccc(NC(=O)C3(CC3)C#N)cc2[nH]1
Structure:
Search PDB for entries with ligand similarity: