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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50192527
Substrate
n/a
Meas. Tech.
ChEMBL_391843 (CHEMBL861265)
IC50
230±n/a nM
Citation
 Ma, V; Bannon, AW; Baumgartner, J; Hale, C; Hsieh, F; Hulme, C; Rorrer, K; Salon, J; van Staden, C; Tempest, P Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists. Bioorg Med Chem Lett 16:5066-72 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1
Type:
PROTEIN
Mol. Mass.:
39133.74
Organism:
Mus musculus
Description:
ChEMBL_818502
Residue:
353
Sequence:
MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50192527
Synonyms:
3-cinnamamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide | CHEMBL215958
Type:
Small organic molecule
Emp. Form.:
C30H33N3O3
Mol. Mass.:
483.6013
SMILES:
Cc1ccc(Oc2ccc(cc2NC(=O)\C=C\c2ccccc2)C(=O)NCCN2CCCC2)cc1C
Structure:
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