Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50192782
Substrate
n/a
Meas. Tech.
ChEMBL_422240 (CHEMBL856508)
IC50
40±n/a nM
Citation
 McDonald, O; Lackey, K; Davis-Ward, R; Wood, E; Samano, V; Maloney, P; Deanda, F; Hunter, R Aza-stilbenes as potent and selective c-RAF inhibitors. Bioorg Med Chem Lett 16:5378-83 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN_MOUSE | Fyn
Type:
PROTEIN
Mol. Mass.:
60675.13
Organism:
Mus musculus
Description:
ChEMBL_422240
Residue:
537
Sequence:
MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50192782
Synonyms:
3,5-dimethyl-4-{(E)-2-[5-(1H-tetrazol-5-yl)-3-pyridinyl]ethenyl}phenol | CHEMBL218791
Type:
Small organic molecule
Emp. Form.:
C16H15N5O
Mol. Mass.:
293.3232
SMILES:
Cc1cc(O)cc(C)c1C=Cc1cncc(c1)-c1nnn[nH]1 |w:10.11|
Structure:
Search PDB for entries with ligand similarity: