Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50193685
Substrate
n/a
Meas. Tech.
ChEMBL_421374 (CHEMBL856556)
EC50
110±n/a nM
Citation
 Jiang, J; Hoang, M; Young, JR; Chaung, D; Eid, R; Turner, C; Lin, P; Tong, X; Wang, J; Tan, C; Feighner, S; Palyha, O; Hreniuk, DL; Pan, J; Sailer, AW; MacNeil, DJ; Howard, A; Shearman, L; Stribling, S; Camacho, R; Strack, A; Van der Ploeg, LH; Goulet, MT; DeVita, RJ 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorg Med Chem Lett 16:5270-4 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50193685
Synonyms:
CHEMBL215981 | N-(1-(6-(3-(4-(trifluoromethyl)phenyl)propanamido)quinolin-2-yl)pyrrolidin-3-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C30H27F3N4O2
Mol. Mass.:
532.5562
SMILES:
FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC(C2)NC(=O)c2ccccc2)cc1
Structure:
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