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Target
Neuromedin-K receptor
Ligand
BDBM50194561
Substrate
n/a
Meas. Tech.
ChEMBL_424424 (CHEMBL910703)
IC50
3.5±n/a nM
Citation
 Elliott, JM; Carling, RW; Chicchi, GG; Crawforth, J; Hutson, PH; Jones, AB; Kelly, S; Marwood, R; Meneses-Lorente, G; Mezzogori, E; Murray, F; Rigby, M; Royo, I; Russell, MG; Shaw, D; Sohal, B; Tsao, KL; Williams, B N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II. Bioorg Med Chem Lett 16:5752-6 (2006) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3)
Type:
Enzyme
Mol. Mass.:
52221.96
Organism:
Homo sapiens (Human)
Description:
P29371
Residue:
465
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM50194561
Synonyms:
CHEMBL375638 | N'-{8-fluoro-2-phenyl-3-[4-(tetrahydro-pyran-4-yl)-piperazin-1-ylmethyl]-quinoline-4-carbonyl}-N-phenyl-hydrazinecarboxylic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C34H36FN5O4
Mol. Mass.:
597.6791
SMILES:
COC(=O)N(NC(=O)c1c(CN2CCN(CC2)C2CCOCC2)c(nc2c(F)cccc12)-c1ccccc1)c1ccccc1
Structure:
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