Reaction Details Report a problem with these data
Target
Glycogen phosphorylase, liver form
Ligand
BDBM50182801
Substrate
n/a
Meas. Tech.
ChEMBL_399836 (CHEMBL910311)
IC50
670±n/a nM
Citation
Oikonomakos, NG; Tiraidis, C; Leonidas, DD; Zographos, SE; Kristiansen, M; Jessen, CU; Nørskov-Lauritsen, L; Agius, L Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. J Med Chem 49:5687-701 (2006) [PubMed] Article
More Info.:
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:
Homodimer
Mol. Mass.:
97153.98
Organism:
Homo sapiens (Human)
Description:
Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:
847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Inhibitor
Name:
BDBM50182801
Synonyms:
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8 | (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE | AFEGOSTAT TARTRATE | CHEMBL206468 | D-Isofagomine | US10081601, Example 1.1 | US9796680, Example Table2.1 | isofagomine
Type:
Small organic molecule
Emp. Form.:
C6H13NO3
Mol. Mass.:
147.1723
SMILES:
OC[C@H]1CNC[C@@H](O)[C@@H]1O |r|