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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50194828
Substrate
n/a
Meas. Tech.
ChEMBL_424570 (CHEMBL853921)
IC50
2.4±n/a nM
Citation
 Swain, CJ; Teran, A; Maroto, M; Cabello, A Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands. Bioorg Med Chem Lett 16:6058-62 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50194828
Synonyms:
CHEMBL218589 | N-(2-methyl-1-phenylpropan-2-yl)-7-p-tolyl-2,3-dihydro-1H-1,4-diazepin-5-amine
Type:
Small organic molecule
Emp. Form.:
C22H27N3
Mol. Mass.:
333.4699
SMILES:
Cc1ccc(cc1)C1=NCCN=C(C1)NC(C)(C)Cc1ccccc1 |c:12,t:8|
Structure:
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