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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50194850
Substrate
n/a
Meas. Tech.
ChEMBL_424570 (CHEMBL853921)
IC50
1.6±n/a nM
Citation
 Swain, CJ; Teran, A; Maroto, M; Cabello, A Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands. Bioorg Med Chem Lett 16:6058-62 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50194850
Synonyms:
7-(4-fluorophenyl)-N-(1-methylcyclohexyl)-2,3-dihydro-1H-1,4-diazepin-5-amine | CHEMBL219215
Type:
Small organic molecule
Emp. Form.:
C18H24FN3
Mol. Mass.:
301.4017
SMILES:
CC1(CCCCC1)NC1=NCCN=C(C1)c1ccc(F)cc1 |c:13,t:9|
Structure:
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