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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50195343
Substrate
n/a
Meas. Tech.
ChEMBL_424915 (CHEMBL908547)
IC50
65±n/a nM
Citation
 Sabat, M; VanRens, JC; Laufersweiler, MJ; Brugel, TA; Maier, J; Golebiowski, A; De, B; Easwaran, V; Hsieh, LC; Walter, RL; Mekel, MJ; Evdokimov, A; Janusz, MJ The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett 16:5973-7 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50195343
Synonyms:
3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(4-methylpiperazin-1-yl)ethoxy)pyrimidin-4-ylamino)-4-methylphenol | CHEMBL220847
Type:
Small organic molecule
Emp. Form.:
C25H29N7O2
Mol. Mass.:
459.5435
SMILES:
CN1CCN(CCOc2cc(Nc3cc(O)ccc3C)nc(n2)-n2cnc3ccccc23)CC1
Structure:
Search PDB for entries with ligand similarity: