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Target
Adenosine receptor A1
Ligand
BDBM50195998
Substrate
n/a
Meas. Tech.
ChEMBL_431897 (CHEMBL917395)
Ki
15±n/a nM
Citation
 Giorgi, I; Bianucci, AM; Biagi, G; Livi, O; Scartoni, V; Leonardi, M; Pietra, D; Coi, A; Massarelli, I; Nofal, FA; Fiamingo, FL; Anastasi, P; Giannini, G Synthesis, biological activity and molecular modelling of new trisubstituted 8-azaadenines with high affinity for A1 adenosine receptors. Eur J Med Chem 42:1-9 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50195998
Synonyms:
3-(2-fluorobenzyl)-N-cyclopropyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine | CHEMBL227798
Type:
Small organic molecule
Emp. Form.:
C20H17FN6
Mol. Mass.:
360.3876
SMILES:
Fc1ccccc1Cn1nnc2c(NC3CC3)nc(nc12)-c1ccccc1
Structure:
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