Target
Sodium-dependent dopamine transporter
Ligand
BDBM50197440
Substrate
n/a
Meas. Tech.
ChEMBL_432256 (CHEMBL914034)
IC50
6.9±n/a nM
Citation
 Pham-Huu, DPDeschamps, JRLiu, SMadras, BKMeltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem 15:1067-82 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3
Type:
PROTEIN
Mol. Mass.:
68455.12
Organism:
Macaca fascicularis
Description:
ChEMBL_61362
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50197440
Synonyms:
2-beta-carbomethoxy-3-alpha-(3,4-dichlorophenyl)-8-thiabicyclo[3.2.1]octane | CHEMBL375262
Type:
Small organic molecule
Emp. Form.:
C15H16Cl2O2S
Mol. Mass.:
331.257
SMILES:
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(Cl)c(Cl)c1)S2 |TLB:11:10:19:6.7,THB:2:4:19:6.7|
Structure:
Search PDB for entries with ligand similarity: