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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50198351
Substrate
n/a
Meas. Tech.
ChEMBL_432577 (CHEMBL918283)
Ki
54000±n/a nM
Citation
 Dixit, M; Tripathi, BK; Tamrakar, AK; Srivastava, AK; Kumar, B; Goel, A Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors. Bioorg Med Chem 15:727-34 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50198351
Synonyms:
1-(7'-acetyl-6,6'-dihydroxy-2',3'-dihydro-[2,3']bibenzofuranyl-7-yl)-ethanone | CHEMBL224039
Type:
Small organic molecule
Emp. Form.:
C20H14O6
Mol. Mass.:
350.3216
SMILES:
CC(=O)c1c(O)ccc2cc(oc12)-c1coc2c(C(C)=O)c(O)ccc12
Structure:
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