Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50199258
Substrate
n/a
Meas. Tech.
ChEMBL_411789 (CHEMBL908945)
IC50
1.1±n/a nM
Citation
 Tavares, FXAl-Barazanji, KABishop, MJBritt, CSCarlton, DLCooper, JPFeldman, PLGarrido, DMGoetz, ASGrizzle, MKHertzog, DLIgnar, DMLang, DGMcIntyre, MSOtt, RJPeat, AJZhou, HQ 6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist. J Med Chem 49:7108-18 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50199258
Synonyms:
6-(4-chlorophenyl)-3-[1-methyl-2-(pyrrolidin-1-ylmethyl)-1Hindol-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one | CHEMBL217887
Type:
Small organic molecule
Emp. Form.:
C26H23ClN4OS
Mol. Mass.:
475.005
SMILES:
Cn1c(CN2CCCC2)cc2cc(ccc12)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: