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Target
Gastric inhibitory polypeptide receptor
Ligand
BDBM50199486
Substrate
n/a
Meas. Tech.
ChEMBL_441040 (CHEMBL890127)
IC50
286±n/a nM
Citation
 Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett 17:587-92 (2007) [PubMed]  Article 
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53173.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1518286
Residue:
466
Sequence:
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
  
Inhibitor
Name:
BDBM50199486
Synonyms:
3-(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(trifluoromethoxy)phenyl)acetamido)-2,3-dihydro-1H-indene-5-carboxamido)propanoic acid | CHEMBL232224
Type:
Small organic molecule
Emp. Form.:
C32H39F3N2O5
Mol. Mass.:
588.6577
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Cc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-1.44,-41.26,;-1.43,-39.72,;.11,-39.73,;-2.97,-39.72,;-1.42,-38.18,;-.09,-37.41,;-.08,-35.87,;-1.4,-35.1,;-2.75,-35.87,;-2.75,-37.4,;-1.41,-33.56,;-.07,-32.8,;.25,-31.29,;2.11,-31.33,;2.58,-32.79,;3.92,-33.55,;3.92,-35.09,;2.59,-35.87,;1.25,-35.1,;1.26,-33.56,;5.26,-35.86,;5.26,-37.4,;6.59,-35.09,;7.92,-35.86,;9.26,-35.08,;10.59,-35.85,;11.92,-35.08,;10.6,-37.39,;-2.74,-32.79,;-2.74,-31.25,;-4.07,-33.57,;-5.41,-32.8,;-6.75,-33.57,;-8.08,-32.8,;-8.08,-31.25,;-9.41,-30.48,;-9.41,-28.94,;-9.43,-27.4,;-7.87,-28.94,;-10.95,-28.95,;-6.75,-30.48,;-5.41,-31.25,)|
Structure:
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